There is at least one ferry a day from Pireaus to Chios. Most days the ferry boats leave Pireaus at around 6pm and arrive in Chios at the ungodly hour of 4am, too early to check into your hotel and too late to waste money paying for a full night. But if you arrive then there are cafes and restaurants that are open where you can hang out. However, I would suggest booking your hotel through a Greek travel agency and asking them to book a transfer so someone from the hotel is there at the dock waiting for you and takes you back to the hotel and if your room is not ready because somebody is in it at least you can hang out in the lobby until the breakfast room opens. And if you are staying somewhere that is not in Chios town all the more reason to book the transfer. You can use my Create-an-itinerary Form and even though it does not list Chios you can write it in under comments. I highly recommend using the form and a Greek travel agency especially if you are doing Chios and other islands. Making ferry connections to any island except Lesvos can be tricky.

Unless you are leaving in the afternoon get a cabin. In fact pay a little extra and get a LUX cabin. The boats to Chios and Lesvos are modern and pretty nice, though there are a couple that are not. Go for Blue Star and Hellenic Seaways if those are your choices.

There have been boats in the past between Chios and Samos, Psara, Samothaki, Kavala, Alexandroupolis, Limnos, Ikaria, Thessaloniki, Kalymnos, Kos and Rhodes which go from once a week to several times a week. There was a boat once or twice a week from Lavrion, near Athens to the port of Mesta in Chios. Whether these boats will be running depends on the financial condition of the ferry companies that run these routes and the demand for them.

There are daily boats to Turkey and the small island of Innousses as well.

Chios has an airport with several daily flights to and from Athens on Aegean Airways.

Chios has a bus service that can get you pretty much anywhere you want to go and if you need to get closer there are taxis. But I recommend renting a car with Aegean Thesaurus who do car rentals all over Greece.

As with all the islands I recommend using a Greek travel agency to book hotels, ferries and rental cars. You can also use my Create-an-itinerary form to put together an itinerary that includes Chios and many of the other Greek islands.

Use Ferryhopper to find all direct and indirect ferry routes for the islands of Greece, Spain, Italy & Turkey, compare ferry companies & prices, and book cheap ferry tickets with no hidden fees in one go!